Endocrine Abstracts

Introduction: Atypical pituitary adenomas are often characterized by rapid growth and massive invasion of the surrounding structures. Usually, they are associated with poor prognosis and high recurrence rate due to resistance to conventional therapies. When surgery and radiation are ineffective, alternative therapies remain the last line treatment. Lately, a novel chemotherapy with capecitabine and temozolomide was proposed as a highly effective and extending the life of the p...

Introduction: Adrenal medullary hyperplasia (AMH) is a rare syndrome of catecholamine excess. Adrenal overgrowth is usually bilateral. Due to similar clinical signs, laboratory results and radiological adrenal picture, AMH can be misdiagnosed as pheochromocytoma. The only method that allows determining a proper diagnosis of AMH is pathologic examination. It is regarded as a precursor of pheochromocytoma and has been reported as a component of MEN2.Aim: T...

Introduction: Type 2 amiodarone-induced thyrotoxicosis (AIT2), resulting from the release of thyroid hormones, is a rarer form of side effect of this drug. Treatment of thyrotoxicosis in patients with end stage renal disease (ESRD) is difficult because hemodialysis alters renal clearance of drugs and iodine, may impact the results of assessment and treatment and can increase the medical instability of patients.Aim: The aim was to present the difficulties...

Introduction: The aim of the study was to examine the risk factors associated with diabetic retinopathy (DR) in adult patients with DM1 and DM2.Design: The study group consisted of adults patients with DM1 and DM2, diagnosed according to the WHO criteria. Risk factors for diabetic retinopathy were evaluated on the demographic data, medical history, clinical and biochemical parameters related to metabolic control of diabetes. We collected also ophthalmic ...

Introduction: The aim of the study was to assess antropometric and metabolic parametres in women with previous gestational diabetes mellitus (GDM) during a 30-month observation.Design: Our prospective study cohort consisted of 367 women with GDM diagnosed according to WHO criteria. Oral glucose tolerance test (OGTT) was performed during 6-10 weeks and 12, 18, 24, 30 months after delivery. On every 6th month between 12th and 30th month after delivery we e...

Macroprolactin is a collective term for a heterogenous group of high molecular mass forms of prolactin with minimal bioactivity in vivo. Objective: to determine prevalence of macroprolactinemia (macroPRL) and clinical characteristics of patients with hyperprolactinemia (hyperPRL) who underwent assessment for macroPRL in Endocrinology outpatient clinic.Methods: We reviewed the medical records of 54 patients who were evaluated for macroPRL between...

Introduction: Hypopituitarism is characterized by the absence of pituitary hormones. Depending on what pituitary hormones are missing and what is the etiology of hypopituitarism, its clinical manifestation varies. Apart from evident symptoms and signs of hypopituitarism due to hormonal insufficiencies, several studies reveal that long-standing hypopituitarism, including particularly absence of GH, is related to higher risk of metabolic syndrome.Objective...

ACTH is a 39 amino acids polypeptide which stimulates adrenocortical steroid production. The N-terminal segment of ACTH(1–24) is biologically active and the C-terminal is considered to have greater antigenicity. In one previous (‘RoSA’) and one current (‘RADS2’) clinical trial synthetic ACTH (zinc tetracosactide; depot synacthen) was administered to autoimmune Addison’s disease (AAD) patients to stimulate adrenocortical regeneration. 4/13 RoSA pat...

Background: Exertional heat illness (EHI) is an incapacitating and sometimes fatal phenomenon. It is associated with elevated core temperature (Tc), cardiovascular instability and the systemic inflammatory response syndrome. EHI-preventive guidelines recommend maintaining Tc ≤38 °C, an important thermoregulatory threshold above which vasomotor compensation plateaus and pronounced excursions in key pituitary and adrenal hormones occur. Copeptin, the C-terminal part o...

Introduction: The aim of the study was to assess if gestational diabetes mellitus (GDM) influence the pregnancy outcomes and the growth patterns in children.Design: Our prospective study cohort consisted of 261 children born to mothers with GDM and 153 control children born to non-diabetic mothers. In both groups children’s weight, length were assessed. Children were matched for large for gestational age (LGA) (birth weight >90th percentile for ...